InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALDH9A1

Summary

InnateDB Gene

IDBG-104484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH9A1

Gene Name

aldehyde dehydrogenase 9 family, member A1

Synonyms

ALDH4; ALDH7; ALDH9; E3; TMABADH

Species

Homo sapiens

Ensembl Gene

ENSG00000143149

Encoded Proteins

IDBP-104486

aldehyde dehydrogenase 9 family, member A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:165662216-165698863

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000354775	ENSP00000346827
ENST00000463610
ENST00000491436
ENST00000461664
ENST00000471457

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0019145	aminobutyraldehyde dehydrogenase activity
GO:0033737	1-pyrroline dehydrogenase activity
GO:0042803	protein homodimerization activity
GO:0043176	amine binding
GO:0047105	4-trimethylammoniobutyraldehyde dehydrogenase activity
GO:0051287	NAD binding

Biological Process

GO:0001822	kidney development
GO:0001889	liver development
GO:0006081	cellular aldehyde metabolic process
GO:0008152	metabolic process
GO:0009437	carnitine metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042445	hormone metabolic process
GO:0044281	small molecule metabolic process
GO:0045329	carnitine biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026687

View Gene Order

ENSBTAG00000017852

Not yet available

Pathways

NETPATH

REACTOME

REACT_2125

Carnitine synthesis pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00010

Glycolysis / Gluconeogenesis pathway

hsa00340

Histidine metabolism pathway

hsa00620

Pyruvate metabolism pathway

hsa00280

Valine, leucine and isoleucine degradation pathway

hsa00330

Arginine and proline metabolism pathway

hsa00380

Tryptophan metabolism pathway

hsa00071

Fatty acid degradation pathway

hsa00310

Lysine degradation pathway

hsa00053

Ascorbate and aldarate metabolism pathway

hsa00410

beta-Alanine metabolism pathway

hsa00561

Glycerolipid metabolism pathway

INOH

INOH website

Tryptophan degradation pathway

INOH website

Propanoate metabolism pathway

INOH website

Arginine Proline metabolism pathway

INOH website

Pyruvate metabolism pathway

INOH website

Valine Leucine Isoleucine degradation pathway

INOH website

Lysine degradation pathway

INOH website

Histidine degradation pathway

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.2533 Hs.618529

RefSeq

NM_000696

HUGO

OMIM

CCDS

CCDS1250

HPRD

04109

IMGT

EMBL

GenPept

RNA Seq Atlas