Homo sapiens Gene: ALDH9A1
Summary
InnateDB Gene IDBG-104484.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH9A1
Gene Name aldehyde dehydrogenase 9 family, member A1
Synonyms ALDH4; ALDH7; ALDH9; E3; TMABADH;
Species Homo sapiens
Ensembl Gene ENSG00000143149
Encoded Proteins
aldehyde dehydrogenase 9 family, member A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:165662216-165698863
Strand Reverse strand
Band q24.1
Transcripts
ENST00000354775 ENSP00000346827
ENST00000463610
ENST00000491436
ENST00000461664
ENST00000471457
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0019145 aminobutyraldehyde dehydrogenase activity
GO:0033737 1-pyrroline dehydrogenase activity
GO:0042803 protein homodimerization activity
GO:0043176 amine binding
GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity
GO:0051287 NAD binding
Biological Process
GO:0001822 kidney development
GO:0001889 liver development
GO:0006081 cellular aldehyde metabolic process
GO:0008152 metabolic process
GO:0009437 carnitine metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042136 neurotransmitter biosynthetic process
GO:0042445 hormone metabolic process
GO:0044281 small molecule metabolic process
GO:0045329 carnitine biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Carnitine synthesis pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Ascorbate and aldarate metabolism pathway
Fatty acid degradation pathway
Valine, leucine and isoleucine degradation pathway
Lysine degradation pathway
Arginine and proline metabolism pathway
Histidine metabolism pathway
Tryptophan metabolism pathway
beta-Alanine metabolism pathway
Glycerolipid metabolism pathway
Pyruvate metabolism pathway
INOH
Lysine degradation pathway
Histidine degradation pathway
Tryptophan degradation pathway
Propanoate metabolism pathway
Arginine Proline metabolism pathway
Pyruvate metabolism pathway
Valine Leucine Isoleucine degradation pathway
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.2533 Hs.618529
RefSeq NM_000696
HUGO
OMIM
CCDS CCDS1250
HPRD 04109
IMGT
EMBL
GenPept
RNA Seq Atlas