InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FASLG

Summary

InnateDB Protein

IDBP-104858.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FASLG

Protein Name

Fas ligand (TNF superfamily, member 6)

Synonyms

ALPS1B; APT1LG1; APTL; CD178; CD95-L; CD95L; FASL; TNFSF6;

Species

Homo sapiens

Ensembl Protein

ENSP00000356694

InnateDB Gene

IDBG-104856 (FASLG)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. {ECO:0000269PubMed:17557115}.The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition. {ECO:0000269PubMed:17557115}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane.Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted {ECO:0000250}. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface. {ECO:0000250}.FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus.

Disease Associations

Autoimmune lymphoproliferative syndrome 1B (ALPS1B) [MIM:601859]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269PubMed:8787672}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 113 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	113 [view]
Protein-Protein	105 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005123	death receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006925	inflammatory cell apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0016525	negative regulation of angiogenesis
GO:0030644	cellular chloride ion homeostasis
GO:0032496	response to lipopolysaccharide
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043525	positive regulation of neuron apoptotic process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0046666	retinal cell programmed cell death
GO:0048388	endosomal lumen acidification
GO:0070231	T cell apoptotic process
GO:0070266	necroptotic process
GO:0070848	response to growth factor
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097527	necroptotic signaling pathway
GO:2000353	positive regulation of endothelial cell apoptotic process
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0043202	lysosomal lumen
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0060205	cytoplasmic membrane-bounded vesicle lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002961 Lymphotoxin-beta
IPR006052 Tumour necrosis factor domain
IPR006053 Tumour necrosis factor
IPR008983 Tumour necrosis factor-like domain
IPR028326 Tumor necrosis factor ligand superfamily member 6

PFAM

PF00229

PRINTS

PR01237
PR01234
PR01681

PIRSF

SMART

SM00207

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt