InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FASLG

Summary

InnateDB Gene

IDBG-104856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FASLG

Gene Name

Fas ligand (TNF superfamily, member 6)

Synonyms

ALPS1B; APT1LG1; APTL; CD178; CD95-L; CD95L; FASL; TNFSF6

Species

Homo sapiens

Ensembl Gene

ENSG00000117560

Encoded Proteins

IDBP-104858

Fas ligand (TNF superfamily, member 6)

IDBP-104860

Fas ligand (TNF superfamily, member 6)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:172659018-172666874

Strand

Forward strand

Band

q24.3

Transcripts

ENST00000367721	ENSP00000356694
ENST00000340030	ENSP00000344739

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 113 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	113 [view]
Protein-Protein	105 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005123	death receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006925	inflammatory cell apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0016525	negative regulation of angiogenesis
GO:0030644	cellular chloride ion homeostasis
GO:0032496	response to lipopolysaccharide
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043525	positive regulation of neuron apoptotic process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0046666	retinal cell programmed cell death
GO:0048388	endosomal lumen acidification
GO:0070231	T cell apoptotic process
GO:0070266	necroptotic process
GO:0070848	response to growth factor
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097527	necroptotic signaling pathway
GO:2000353	positive regulation of endothelial cell apoptotic process
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0043202	lysosomal lumen
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0060205	cytoplasmic membrane-bounded vesicle lumen
GO:0070062	extracellular vesicular exosome