InnateDB Protein
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IDBP-104860.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FASLG
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Protein Name
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Fas ligand (TNF superfamily, member 6)
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Synonyms
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ALPS1B; APT1LG1; APTL; CD178; CD95-L; CD95L; FASL; TNFSF6;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344739
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InnateDB Gene
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IDBG-104856 (FASLG)
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Protein Structure
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Function |
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. {ECO:0000269PubMed:17557115}.The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition. {ECO:0000269PubMed:17557115}.
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Subcellular Localization |
Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane.Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted {ECO:0000250}. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface. {ECO:0000250}.FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus.
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Disease Associations |
Autoimmune lymphoproliferative syndrome 1B (ALPS1B) [MIM:601859]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269PubMed:8787672}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 113 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
113
[view]
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Protein-Protein |
105
[view]
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Protein-DNA |
6
[view]
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0006915
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apoptotic process
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0006955
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immune response
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GO:0007165
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signal transduction
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GO:0007267
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cell-cell signaling
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GO:0008625
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extrinsic apoptotic signaling pathway via death domain receptors
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GO:0016525
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negative regulation of angiogenesis
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GO:0043065
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positive regulation of apoptotic process
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0070231
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T cell apoptotic process
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GO:0070266
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necroptotic process
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GO:0097190
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apoptotic signaling pathway
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GO:0097191
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extrinsic apoptotic signaling pathway
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GO:0097527
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necroptotic signaling pathway
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GO:2000353
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positive regulation of endothelial cell apoptotic process
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GO:2001239
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regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Cellular Component |
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PDB ID |
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InterPro |
IPR028326
Tumor necrosis factor ligand superfamily member 6
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PFAM |
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PRINTS |
PR01681
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P48023
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PhosphoSite |
PhosphoSite-P48023
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
356
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UniGene |
Hs.2007
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RefSeq |
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HUGO |
HGNC:11936
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OMIM |
134638
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CCDS |
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HPRD |
00610
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IMGT |
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EMBL |
AB013303
AF288573
BC017502
D38122
U08137
U11821
X89102
Z96050
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GenPept |
AAC50071
AAC50124
AAG60017
AAH17502
BAA07320
BAA32542
CAA61474
CAB09424
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