InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNASEL

Summary

InnateDB Protein

IDBP-105250.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNASEL

Protein Name

ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Synonyms

PRCA1; RNS4;

Species

Homo sapiens

Ensembl Protein

ENSP00000356530

InnateDB Gene

IDBG-105248 (RNASEL)

Protein Structure

UniProt Annotation

Function

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. {ECO:0000269PubMed:11585831}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11585831}. Mitochondrion {ECO:0000269PubMed:11585831}.

Disease Associations

Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004521	endoribonuclease activity
GO:0004540	ribonuclease activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019843	rRNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006364	rRNA processing
GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0019221	cytokine-mediated signaling pathway
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005575	cellular_component
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR006567 PUG domain
IPR010440 Lipopolysaccharide kinase
IPR010513 KEN domain
IPR011009 Protein kinase-like domain
IPR020683 Ankyrin repeat-containing domain

PFAM