Version 5.4
Homo sapiens Gene: RNASEL
Summary
InnateDB Gene IDBG-105248.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASEL
Gene Name ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Synonyms PRCA1; RNS4
Species Homo sapiens
Ensembl Gene ENSG00000135828
Encoded Proteins
IDBP-105250
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
IDBP-594521
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19075243
RNASEL, antiviral endoribonuclease, is the terminal component of an RNA decay pathway that is an important mediator of IFN-induced antiviral activity and is required for the optimal induction of pro-inflammatory cytokines that play essential roles in host defence from bacterial pathogens.
PMID 19075243
RNASEL regulates the expression of the endolysosomal protease, cathepsin-E, and endosome-associated activities, that function to eliminate internalized bacteria and may contribute to RNASEL antimicrobial action.
PMID 20833746
RNASEL-mediated cleavage of Hepatitis C virus (HCV) RNA generates suppressor of virus RNA (svRNA) that activates DDX58 (RIG-I), thus propagating innate immune signalling to the interferon (IFN)-beta gene.
PMID 21190483
RNASEL cleaves RNA during viral infections and the cleavage products induces the RIG-I pathway and production of IFNB gene. In addition, RNASEL is implicated in the protection of central nervous system against viral-induced demyelination. A broader role in innate immunity is suggested by involvement of RNASEL in cytokine induction and endosomal pathways that suppress bacterial infections.
PMID 25816776
RNA cleavage products, catalyzed by RNASEL, bind to DHX33 to facilitate the formation of a complex with MAVS and NLRP3 during viral infection.
InnateDB Annotation from Orthologs
Summary
PMID 21190483
[Mus musculus] Rnasel cleaves RNA during viral infections and the cleavage products induces the RIG-I pathway and production of Ifnb gene. In addition, Rnasel is implicated in the protection of central nervous system against viral-induced demyelination. A broader role in innate immunity is suggested by involvement of Rnasel in cytokine induction and endosomal pathways that suppress bacterial infections.
PMID 24324683
[Mus musculus] RNASEL contributes to innate immunity through regulating macrophage functions.
Entrez Gene
Summary This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:182573634-182589256
Strand Reverse strand
Band q25.3
Transcripts
ENST00000367559 ENSP00000356530
ENST00000539397 ENSP00000440844
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004521 endoribonuclease activity
GO:0004540 ribonuclease activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0019221 cytokine-mediated signaling pathway
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066800
View Gene Order
ENSBTAG00000009091
Not yet available
Pathways
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518545 Hs.611876
RefSeq NM_021133 XM_005245411
HUGO
OMIM
CCDS CCDS1347
HPRD 01590
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca