InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS16

Summary

InnateDB Protein

IDBP-105255.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS16

Protein Name

regulator of G-protein signaling 16

Synonyms

A28-RGS14; A28-RGS14P; RGS-R;

Species

Homo sapiens

Ensembl Protein

ENSP00000356529

InnateDB Gene

IDBG-105253 (RGS16)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade.

Subcellular Localization

Disease Associations

Tissue Specificity

Abundantly expressed in retina with lower levels of expression in most other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	15 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0007601	visual perception
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity