InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G4A

Summary

InnateDB Protein

IDBP-105431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G4A

Protein Name

phospholipase A2, group IVA (cytosolic, calcium-dependent)

Synonyms

cPLA2-alpha; PLA2G4;

Species

Homo sapiens

Ensembl Protein

ENSP00000356436

InnateDB Gene

IDBG-105429 (PLA2G4A)

Protein Structure

UniProt Annotation

Function

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Subcellular Localization

Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

Disease Associations

Note=PLA2G4A mutations resulting in phospholipase A2 deficiency have been found in a patient affected by recurrent episodes of multiple complicated ulcers of the small intestine, not due to cyclooxygenase inhibitors use. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis (PubMed:18451993). {ECO:0000269PubMed:18451993}.

Tissue Specificity

Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	47 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0004622	lysophospholipase activity
GO:0004623	phospholipase A2 activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006663	platelet activating factor biosynthetic process
GO:0006690	icosanoid metabolic process
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0009395	phospholipid catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0030168	platelet activation
GO:0035965	cardiolipin acyl-chain remodeling
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0042127	regulation of cell proliferation
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046456	icosanoid biosynthetic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050482	arachidonic acid secretion
GO:0071236	cellular response to antibiotic

Cellular Component

GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016023	cytoplasmic membrane-bounded vesicle