InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLA2G4A

Summary

InnateDB Gene

IDBG-105429.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G4A

Gene Name

phospholipase A2, group IVA (cytosolic, calcium-dependent)

Synonyms

cPLA2-alpha; PLA2G4

Species

Homo sapiens

Ensembl Gene

ENSG00000116711

Encoded Proteins

IDBP-105431

phospholipase A2, group IVA (cytosolic, calcium-dependent)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22003202

PLA2G4A and its metabolite lipid mediators induce autophagy in macrophages and monocytes. This autophagy is ATG5 dependent and independent of changes in mTOR or autophagic flux. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22003202

[Mus musculus] Pla2g4a and its metabolite lipid mediators induce autophagy in macrophages and monocytes. This autophagy is Atg5 dependent and independent of changes in mTOR or autophagic flux.

Entrez Gene

Summary

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:186828953-186988981

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000367466	ENSP00000356436
ENST00000466600

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	47 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0004622	lysophospholipase activity
GO:0004623	phospholipase A2 activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006663	platelet activating factor biosynthetic process
GO:0006690	icosanoid metabolic process
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0009395	phospholipid catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0030168	platelet activation
GO:0035965	cardiolipin acyl-chain remodeling
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0042127	regulation of cell proliferation
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046456	icosanoid biosynthetic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050482	arachidonic acid secretion
GO:0071236	cellular response to antibiotic

Cellular Component

GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016023	cytoplasmic membrane-bounded vesicle