Homo sapiens Gene: PLA2G4A
InnateDB Gene IDBG-105429.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G4A
Gene Name phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms cPLA2-alpha; PLA2G4
Species Homo sapiens
Ensembl Gene ENSG00000116711
Encoded Proteins
phospholipase A2, group IVA (cytosolic, calcium-dependent)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
PLA2G4A and its metabolite lipid mediators induce autophagy in macrophages and monocytes. This autophagy is ATG5 dependent and independent of changes in mTOR or autophagic flux. (Demonstrated in mice)
InnateDB Annotation from Orthologs
[Mus musculus] Pla2g4a and its metabolite lipid mediators induce autophagy in macrophages and monocytes. This autophagy is Atg5 dependent and independent of changes in mTOR or autophagic flux.
Entrez Gene
Summary This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:186828953-186988981
Strand Forward strand
Band q31.1
ENST00000367466 ENSP00000356436
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 47 [view]
Protein-DNA 4 [view]
Protein-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004620 phospholipase activity
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006663 platelet activating factor biosynthetic process
GO:0006690 icosanoid metabolic process
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
GO:0019369 arachidonic acid metabolic process
GO:0030168 platelet activation
GO:0035965 cardiolipin acyl-chain remodeling
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0042127 regulation of cell proliferation
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0046456 icosanoid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0050482 arachidonic acid secretion
GO:0071236 cellular response to antibiotic
Cellular Component
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016023 cytoplasmic membrane-bounded vesicle
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
IL1 pathway
IL5 pathway
Platelet sensitization by LDL pathway
Platelet homeostasis pathway
ADP signalling through P2Y purinoceptor 1 pathway
phospho-PLA2 pathway pathway
PLC beta mediated events pathway
Opioid Signalling pathway
Arachidonic acid metabolism pathway
Acyl chain remodelling of PC pathway
Acyl chain remodelling of PI pathway
Hydrolysis of LPC pathway
Acyl chain remodelling of PS pathway
Synthesis of PA pathway
Acyl chain remodelling of PG pathway
Acyl chain remodelling of PE pathway
Acyl chain remodeling of CL pathway
Metabolism of lipids and lipoproteins pathway
Signaling by GPCR pathway
Glycerophospholipid biosynthesis pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
G-protein mediated events pathway
Phospholipid metabolism pathway
Metabolism pathway
Signal amplification pathway
Ca-dependent events pathway
Hemostasis pathway
alpha-Linolenic acid metabolism pathway
GnRH signaling pathway pathway
Arachidonic acid metabolism pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
MAPK signaling pathway pathway
Glycerophospholipid metabolism pathway
Linoleic acid metabolism pathway
Long-term depression pathway
Ether lipid metabolism pathway
Fc gamma R-mediated phagocytosis pathway
Vascular smooth muscle contraction pathway
Signaling mediated by p38-alpha and p38-beta
Fc-epsilon receptor I signaling in mast cells
PDGFR-beta signaling pathway
SwissProt P47712
UniProt Splice Variant
Entrez Gene 5321
UniGene Hs.497200
RefSeq NM_024420 XM_005245267
OMIM 600522
EMBL AL022147 AL049797 AY552098 BC114340 M68874 M72393
GenPept AAA60105 AAB00789 AAI14341 AAS45712 CAB42689 CAI22252
RNA Seq Atlas 5321