InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS1

Summary

InnateDB Protein

IDBP-105445.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS1

Protein Name

regulator of G-protein signaling 1

Synonyms

1R20; BL34; HEL-S-87; IER1; IR20;

Species

Homo sapiens

Ensembl Protein

ENSP00000356429

InnateDB Gene

IDBG-105443 (RGS1)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.

Subcellular Localization

Disease Associations

Tissue Specificity

B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005516	calmodulin binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity