InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHLDA3

Summary

InnateDB Protein

IDBP-105770.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHLDA3

Protein Name

pleckstrin homology-like domain, family A, member 3

Synonyms

TIH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000356278

InnateDB Gene

IDBG-105766 (PHLDA3)

Protein Structure

UniProt Annotation

Function

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. {ECO:0000269PubMed:19203586}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19203586}. Membrane {ECO:0000269PubMed:19203586}; Peripheral membrane protein {ECO:0000269PubMed:19203586}.

Disease Associations

Tissue Specificity

Widely expressed with lowest expression in liver and spleen. {ECO:0000269PubMed:10594239}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0010314	phosphatidylinositol-5-phosphate binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0009653	anatomical structure morphogenesis
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065	positive regulation of apoptotic process
GO:0051898	negative regulation of protein kinase B signaling