InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYOG

Summary

InnateDB Protein

IDBP-105920.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYOG

Protein Name

myogenin (myogenic factor 4)

Synonyms

bHLHc3; myf-4; MYF4;

Species

Homo sapiens

Ensembl Protein

ENSP00000241651

InnateDB Gene

IDBG-105918 (MYOG)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin- remodeling and transcription initiation in developing embryos. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0001503	ossification
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0007517	muscle organ development
GO:0007519	skeletal muscle tissue development
GO:0008285	negative regulation of cell proliferation
GO:0010831	positive regulation of myotube differentiation
GO:0014737	positive regulation of muscle atrophy
GO:0014842	regulation of satellite cell proliferation
GO:0014873	response to muscle activity involved in regulation of muscle adaptation
GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation
GO:0014891	striated muscle atrophy
GO:0014894	response to denervation involved in regulation of muscle adaptation
GO:0014902	myotube differentiation
GO:0042692	muscle cell differentiation
GO:0042693	muscle cell fate commitment
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0045663	positive regulation of myoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048741	skeletal muscle fiber development
GO:0048743	positive regulation of skeletal muscle fiber development
GO:0051149	positive regulation of muscle cell differentiation
GO:0071158	positive regulation of cell cycle arrest
GO:0071285	cellular response to lithium ion
GO:0071363	cellular response to growth factor stimulus
GO:0071392	cellular response to estradiol stimulus
GO:1901739	regulation of myoblast fusion