Version 5.4
Homo sapiens Gene: MYOG
Summary
InnateDB Gene IDBG-105918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYOG
Gene Name myogenin (myogenic factor 4)
Synonyms bHLHc3; myf-4; MYF4
Species Homo sapiens
Ensembl Gene ENSG00000122180
Encoded Proteins
IDBP-105920
myogenin (myogenic factor 4)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:203083132-203086036
Strand Reverse strand
Band q32.1
Transcripts
ENST00000241651 ENSP00000241651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0001503 ossification
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0008285 negative regulation of cell proliferation
GO:0010831 positive regulation of myotube differentiation
GO:0014737 positive regulation of muscle atrophy
GO:0014842 regulation of satellite cell proliferation
GO:0014873 response to muscle activity involved in regulation of muscle adaptation
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014891 striated muscle atrophy
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0014902 myotube differentiation
GO:0042692 muscle cell differentiation
GO:0042693 muscle cell fate commitment
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0045663 positive regulation of myoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048741 skeletal muscle fiber development
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0051149 positive regulation of muscle cell differentiation
GO:0071158 positive regulation of cell cycle arrest
GO:0071285 cellular response to lithium ion
GO:0071363 cellular response to growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:1901739 regulation of myoblast fusion
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0032993 protein-DNA complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026459
View Gene Order
ENSBTAG00000006030
Not yet available
Pathways
NETPATH
NetPath_5
ID pathway
REACTOME
REACT_21402
CDO in myogenesis pathway
REACT_111045
Developmental Biology pathway
REACT_21303
Myogenesis pathway
KEGG
INOH
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt P15173
TrEMBL
UniProt Splice Variant
Entrez Gene 4656
UniGene Hs.2830
RefSeq NM_002479
HUGO HGNC:7612
OMIM 159980
CCDS CCDS1433
HPRD 01167
IMGT
EMBL BC053899 BT007233 CH471067 X17651 X62155
GenPept AAH53899 AAP35897 CAA35641 CAA44080 EAW91463
RNA Seq Atlas 4656

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca