InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: REN

Summary

InnateDB Protein

IDBP-106026.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

REN

Protein Name

renin

Synonyms

HNFJ2;

Species

Homo sapiens

Ensembl Protein

ENSP00000272190

InnateDB Gene

IDBG-106022 (REN)

Protein Structure

UniProt Annotation

Function

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Subcellular Localization

Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.

Disease Associations

Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.Familial juvenile hyperuricemic nephropathy 2 (HNFJ2) [MIM:613092]: A renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. {ECO:0000269PubMed:19664745}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005102	receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0008233	peptidase activity

Biological Process

GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0002003	angiotensin maturation
GO:0002016	regulation of blood volume by renin-angiotensin
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0006508	proteolysis
GO:0008217	regulation of blood pressure
GO:0008584	male gonad development
GO:0009755	hormone-mediated signaling pathway
GO:0010033	response to organic substance
GO:0032496	response to lipopolysaccharide
GO:0035690	cellular response to drug
GO:0035902	response to immobilization stress
GO:0042493	response to drug
GO:0042756	drinking behavior
GO:0043408	regulation of MAPK cascade
GO:0044267	cellular protein metabolic process
GO:0048469	cell maturation
GO:0050435	beta-amyloid metabolic process
GO:0051591	response to cAMP
GO:0070305	response to cGMP