InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: REN

Summary

InnateDB Gene

IDBG-106022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

REN

Gene Name

renin

Synonyms

HNFJ2

Species

Homo sapiens

Ensembl Gene

ENSG00000143839

Encoded Proteins

IDBP-106026

renin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:204154819-204166322

Strand

Reverse strand

Band

q32.1

Transcripts

ENST00000272190

ENSP00000272190

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005102	receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0008233	peptidase activity

Biological Process

GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0002003	angiotensin maturation
GO:0002016	regulation of blood volume by renin-angiotensin
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0006508	proteolysis
GO:0008217	regulation of blood pressure
GO:0008584	male gonad development
GO:0009755	hormone-mediated signaling pathway
GO:0010033	response to organic substance
GO:0032496	response to lipopolysaccharide
GO:0035690	cellular response to drug
GO:0035902	response to immobilization stress
GO:0042493	response to drug
GO:0042756	drinking behavior
GO:0043408	regulation of MAPK cascade
GO:0044267	cellular protein metabolic process
GO:0048469	cell maturation
GO:0050435	beta-amyloid metabolic process
GO:0051591	response to cAMP
GO:0070305	response to cGMP

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000070645

View Gene Order

ENSBTAG00000021333

Not yet available

Pathways

NETPATH

REACTOME

REACT_147707

Metabolism of Angiotensinogen to Angiotensins pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

hsa04614

Renin-angiotensin system pathway

INOH

PID NCI

Cross-References

SwissProt

P00797

TrEMBL

Q9UQK5

UniProt Splice Variant

Entrez Gene

5972

UniGene

Hs.3210

RefSeq

NM_000537

HUGO

HGNC:9958

OMIM

179820

CCDS

CCDS30981

HPRD

IMGT

EMBL

AF117822 AL592114 AL592146 AY436324 BC033474 BC047752 CR536498 EU332871 L00064 L00065 L00066 L00067 L00068 L00069 L00070 L00071 L00072 L00073 M10030 M10128 M10150 M10151 M10152 M13253 M15410 M26440 M26899 M26900 M26901

GenPept

AAA60262 AAA60263 AAA60363 AAA60364 AAA60365 AAD03461 AAD26254 AAH33474 AAH47752 AAR03502 ABY87560 CAG38737 CAH71224 CAI16594

RNA Seq Atlas

5972