Homo sapiens Gene: REN
Summary
InnateDB Gene IDBG-106022.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REN
Gene Name renin
Synonyms HNFJ2;
Species Homo sapiens
Ensembl Gene ENSG00000143839
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:204154819-204166322
Strand Reverse strand
Band q32.1
Transcripts
ENST00000272190 ENSP00000272190
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0005102 receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0008233 peptidase activity
Biological Process
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0002003 angiotensin maturation
GO:0002016 regulation of blood volume by renin-angiotensin
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0006508 proteolysis
GO:0008217 regulation of blood pressure
GO:0008584 male gonad development
GO:0009755 hormone-mediated signaling pathway
GO:0010033 response to organic substance
GO:0032496 response to lipopolysaccharide
GO:0035690 cellular response to drug
GO:0035902 response to immobilization stress
GO:0042493 response to drug
GO:0042756 drinking behavior
GO:0043408 regulation of MAPK cascade
GO:0044267 cellular protein metabolic process
GO:0048469 cell maturation
GO:0050435 beta-amyloid metabolic process
GO:0051591 response to cAMP
GO:0070305 response to cGMP
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of Angiotensinogen to Angiotensins pathway
Metabolism of proteins pathway
Peptide hormone metabolism pathway
KEGG
Renin-angiotensin system pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P00797
TrEMBL Q9UQK5
UniProt Splice Variant
Entrez Gene 5972
UniGene Hs.3210
RefSeq NM_000537
HUGO HGNC:9958
OMIM 179820
CCDS CCDS30981
HPRD
IMGT
EMBL AF117822 AL592114 AL592146 AY436324 BC033474 BC047752 CR536498 EU332871 L00064 L00065 L00066 L00067 L00068 L00069 L00070 L00071 L00072 L00073 M10030 M10128 M10150 M10151 M10152 M13253 M15410 M26440 M26899 M26900 M26901
GenPept AAA60262 AAA60263 AAA60363 AAA60364 AAA60365 AAD03461 AAD26254 AAH33474 AAH47752 AAR03502 ABY87560 CAG38737 CAH71224 CAI16594
RNA Seq Atlas 5972