InnateDB Protein
|
IDBP-106103.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
RBBP5
|
Protein Name
|
retinoblastoma binding protein 5
|
Synonyms
|
RBQ3; SWD1;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000264515
|
InnateDB Gene
|
IDBG-106101 (RBBP5)
|
Protein Structure
|
|
Function |
In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. {ECO:0000250, ECO:0000269PubMed:19556245}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:17355966}.
|
Disease Associations |
|
Tissue Specificity |
Ubiquitously expressed.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
112
[view]
|
Protein-Protein |
110
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
1
[view]
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
13 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005515
|
protein binding
|
GO:0035064
|
methylated histone binding
|
GO:0042800
|
histone methyltransferase activity (H3-K4 specific)
|
GO:0044212
|
transcription regulatory region DNA binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
|
PFAM |
PF00400
|
PRINTS |
|
PIRSF |
|
SMART |
SM00320
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q15291
|
PhosphoSite |
PhosphoSite-Q15291
|
TrEMBL |
A0A024R9B5
|
UniProt Splice Variant |
|
Entrez Gene |
5929
|
UniGene |
Hs.737357
|
RefSeq |
NP_005048
|
HUGO |
HGNC:9888
|
OMIM |
600697
|
CCDS |
CCDS30983
|
HPRD |
02826
|
IMGT |
|
EMBL |
AC093422
AK290137
AL583832
BC037284
BC053856
BC075059
BC075060
CH471067
X85134
|
GenPept |
AAH37284
AAH53856
AAH75059
AAH75060
BAF82826
CAA59446
CAI15286
CAI15287
EAW91537
EAW91538
EAW91539
|
|
|