Homo sapiens Gene: RBBP5
Summary
InnateDB Gene IDBG-106101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBBP5
Gene Name retinoblastoma binding protein 5
Synonyms RBQ3; SWD1;
Species Homo sapiens
Ensembl Gene ENSG00000117222
Encoded Proteins
retinoblastoma binding protein 5
retinoblastoma binding protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:205086142-205122015
Strand Reverse strand
Band q32.1
Transcripts
ENST00000264515 ENSP00000264515
ENST00000367164 ENSP00000356132
ENST00000484379
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 112 [view]
Protein-Protein 110 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035064 methylated histone binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0043627 response to estrogen
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
GO:0071339 MLL1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
deactivation of the beta-catenin transactivating complex pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q15291
TrEMBL A0A024R9B5
UniProt Splice Variant
Entrez Gene 5929
UniGene Hs.519230 Hs.737357
RefSeq NM_001193273 NM_005057 XM_005245398 XM_005245399 XM_006711477 NM_001193272 XM_005245400 XM_005245401
HUGO HGNC:9888
OMIM 600697
CCDS CCDS30983 CCDS53463
HPRD 02826
IMGT
EMBL AC093422 AK290137 AL583832 BC037284 BC053856 BC075059 BC075060 CH471067 X85134
GenPept AAH37284 AAH53856 AAH75059 AAH75060 BAF82826 CAA59446 CAI15286 CAI15287 EAW91537 EAW91538 EAW91539
RNA Seq Atlas 5929