InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RBBP5

Summary

InnateDB Gene

IDBG-106101.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBBP5

Gene Name

retinoblastoma binding protein 5

Synonyms

RBQ3; SWD1

Species

Homo sapiens

Ensembl Gene

ENSG00000117222

Encoded Proteins

IDBP-106103

retinoblastoma binding protein 5

IDBP-106105

retinoblastoma binding protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:205086142-205122015

Strand

Reverse strand

Band

q32.1

Transcripts

ENST00000264515	ENSP00000264515
ENST00000367164	ENSP00000356132
ENST00000484379

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	112 [view]
Protein-Protein	110 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0043627	response to estrogen
GO:0051568	histone H3-K4 methylation