InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD34

Summary

InnateDB Protein

IDBP-106401.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD34

Protein Name

CD34 molecule

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000348916

InnateDB Gene

IDBG-106399 (CD34)

Protein Structure

UniProt Annotation

Function

Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008134	transcription factor binding
GO:0030246	carbohydrate binding

Biological Process

GO:0001894	tissue homeostasis
GO:0001935	endothelial cell proliferation
GO:0003094	glomerular filtration
GO:0003158	endothelium development
GO:0006536	glutamate metabolic process
GO:0007165	signal transduction
GO:0008217	regulation of blood pressure
GO:0008283	cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0016337	single organismal cell-cell adhesion
GO:0030097	hemopoiesis
GO:0030195	negative regulation of blood coagulation
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032733	positive regulation of interleukin-10 production
GO:0035759	mesangial cell-matrix adhesion
GO:0038001	paracrine signaling
GO:0042482	positive regulation of odontogenesis
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045766	positive regulation of angiogenesis
GO:0048870	cell motility
GO:0050776	regulation of immune response
GO:0050900	leukocyte migration
GO:0060290	transdifferentiation
GO:0061042	vascular wound healing
GO:0071425	hematopoietic stem cell proliferation
GO:0071636	positive regulation of transforming growth factor beta production
GO:0071657	positive regulation of granulocyte colony-stimulating factor production
GO:0071971	extracellular vesicular exosome assembly
GO:0072011	glomerular endothelium development
GO:0072089	stem cell proliferation
GO:0072254	metanephric glomerular mesangial cell differentiation
GO:1900035	negative regulation of cellular response to heat
GO:1900038	negative regulation of cellular response to hypoxia
GO:1900041	negative regulation of interleukin-2 secretion
GO:1900168	positive regulation of glial cell line-derived neurotrophic factor secretion
GO:1901215	negative regulation of neuron death
GO:2001214	positive regulation of vasculogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009925	basal plasma membrane
GO:0016324	apical plasma membrane
GO:0036053	glomerular endothelium fenestra
GO:0045171	intercellular bridge
GO:0048471	perinuclear region of cytoplasm