Version 5.4
Homo sapiens Gene: CD34
Summary
InnateDB Gene IDBG-106399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD34
Gene Name CD34 molecule
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174059
Encoded Proteins
IDBP-106401
CD34 molecule
IDBP-106405
CD34 molecule
IDBP-106407
CD34 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:207880972-207911402
Strand Reverse strand
Band q32.2
Transcripts
ENST00000356522 ENSP00000348916
ENST00000310833 ENSP00000310036
ENST00000367036 ENSP00000356003
ENST00000485761
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008134 transcription factor binding
GO:0030246 carbohydrate binding
GO:0043199 sulfate binding
Biological Process
GO:0001894 tissue homeostasis
GO:0001935 endothelial cell proliferation
GO:0003094 glomerular filtration
GO:0003158 endothelium development
GO:0006536 glutamate metabolic process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0008217 regulation of blood pressure
GO:0008283 cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016337 single organismal cell-cell adhesion
GO:0030097 hemopoiesis
GO:0030195 negative regulation of blood coagulation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032733 positive regulation of interleukin-10 production
GO:0035759 mesangial cell-matrix adhesion
GO:0038001 paracrine signaling
GO:0042482 positive regulation of odontogenesis
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0048870 cell motility
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
GO:0060290 transdifferentiation
GO:0061042 vascular wound healing
GO:0071425 hematopoietic stem cell proliferation
GO:0071636 positive regulation of transforming growth factor beta production
GO:0071657 positive regulation of granulocyte colony-stimulating factor production
GO:0071971 extracellular vesicular exosome assembly
GO:0072011 glomerular endothelium development
GO:0072089 stem cell proliferation
GO:0072254 metanephric glomerular mesangial cell differentiation
GO:1900035 negative regulation of cellular response to heat
GO:1900038 negative regulation of cellular response to hypoxia
GO:1900041 negative regulation of interleukin-2 secretion
GO:1900168 positive regulation of glial cell line-derived neurotrophic factor secretion
GO:1901215 negative regulation of neuron death
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0036053 glomerular endothelium fenestra
GO:0045171 intercellular bridge
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016494
View Gene Order
ENSBTAG00000010562
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt P28906
TrEMBL Q8IUM0
UniProt Splice Variant
Entrez Gene 947
UniGene Hs.644413
RefSeq NM_001773 NM_001025109
HUGO HGNC:1662
OMIM 142230
CCDS CCDS31012 CCDS31011
HPRD 00790
IMGT
EMBL AF523361 AF538601 AK291529 AL356275 BC039146 CH471100 M81104 M81938 M81939 M81940 M81941 M81942 M81943 M81944 M81945 S53910 S53911
GenPept AAA03181 AAA03659 AAB25222 AAB25223 AAH39146 AAM82157 AAN15135 BAF84218 CAI40195 CAI40196 EAW93459
RNA Seq Atlas 947

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca