Version 5.4
Homo sapiens Protein: HHAT
Summary
InnateDB Protein IDBP-106481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HHAT
Protein Name hedgehog acyltransferase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355977
InnateDB Gene IDBG-106475 (HHAT)
Protein Structure
UniProt Annotation
Function Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (By similarity). May bind GTP. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed in normal tissues and cancer cell lines. {ECO:0000269PubMed:11160356}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
GO:0007275 multicellular organismal development
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
PFAM PF03062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VTY9
PhosphoSite PhosphoSite-Q5VTY9
TrEMBL F5H2Y1
UniProt Splice Variant
Entrez Gene 55733
UniGene Hs.58650
RefSeq NP_001164051
HUGO HGNC:18270
OMIM 605743
CCDS CCDS1495
HPRD 12041
IMGT
EMBL AC096636 AK001586 AK092186 AK297193 AK298991 AK302955 AK316190 AK316524 AL034351 AL035414 AL049848 AL590653 AL691441 BC117130 BX255872 CH471100 CR936628
GenPept AAI17131 BAA91772 BAG52495 BAH12521 BAH12917 BAH13854 BAH14561 BAH14895 CAB42852 CAH70523 CAI17039 CAI22284 CAI23103 CAI23104 CAI56771 EAW93427 EAW93428 EAW93430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca