Version 5.4
Homo sapiens Gene: HHAT
Summary
InnateDB Gene IDBG-106475.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HHAT
Gene Name hedgehog acyltransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000054392
Encoded Proteins
IDBP-106477
hedgehog acyltransferase
IDBP-106481
hedgehog acyltransferase
IDBP-106483
hedgehog acyltransferase
IDBP-389999
hedgehog acyltransferase
IDBP-390000
hedgehog acyltransferase
IDBP-599605
hedgehog acyltransferase
IDBP-588473
hedgehog acyltransferase
IDBP-590070
hedgehog acyltransferase
IDBP-585592
hedgehog acyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary 'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:210328252-210676296
Strand Forward strand
Band q32.2
Transcripts
ENST00000261458 ENSP00000261458
ENST00000367010 ENSP00000355977
ENST00000367009 ENSP00000355976
ENST00000413764 ENSP00000416845
ENST00000426968 ENSP00000413399
ENST00000545154 ENSP00000438468
ENST00000541565 ENSP00000444995
ENST00000537898 ENSP00000442625
ENST00000545781 ENSP00000439229
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
GO:0016409 palmitoyltransferase activity
Biological Process
GO:0007224 smoothened signaling pathway
GO:0007275 multicellular organismal development
GO:0018345 protein palmitoylation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000037375
View Gene Order
Pathways
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_228209
Hh ligand biogenesis disease pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.58650
RefSeq NM_001122834 NM_001170564 NM_001170580 NM_001170587 NM_001170588 NM_018194 XM_006711441
HUGO
OMIM
CCDS CCDS1495 CCDS53471 CCDS53472 CCDS53473
HPRD 12041
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca