InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRAF5

Summary

InnateDB Protein

IDBP-106496.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAF5

Protein Name

TNF receptor-associated factor 5

Synonyms

MGC:39780; RNF84;

Species

Homo sapiens

Ensembl Protein

ENSP00000336825

InnateDB Gene

IDBG-106494 (TRAF5)

Protein Structure

UniProt Annotation

Function

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. {ECO:0000269PubMed:15121867}.

Subcellular Localization

Cytoplasm {ECO:0000305PubMed:15121867}. Cytoplasm, cytosol {ECO:0000269PubMed:15121867}.

Disease Associations

Tissue Specificity

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	71 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0016567	protein ubiquitination
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity