Version 5.4
Homo sapiens Gene: TRAF5
Summary
InnateDB Gene IDBG-106494.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAF5
Gene Name TNF receptor-associated factor 5
Synonyms MGC:39780; RNF84
Species Homo sapiens
Ensembl Gene ENSG00000082512
Encoded Proteins
IDBP-106496
TNF receptor-associated factor 5
IDBP-106498
TNF receptor-associated factor 5
IDBP-106500
TNF receptor-associated factor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 11479302
TRAF5 is a signal transducer for the TNF receptor superfamily that is involved in TNF-induced NF-kappaB activation and protection from cell death.
PMID 19017969
TRAF5, along with other TRAFs, is recruited to many TNF-receptor (TNF-R) superfamily members and is an important modulator of the proximal signaling events that occur at the time of receptor engagement and activation. TRAF5 has been shown to be a positive regulator of a number of these receptors that are involved in T cell co-stimulation.
PMID 20161788
TRAF5, a ubiquitin ligase, is a key molecule in the innate response against viral infection where it mediates the activation of IRF3 and NF-kappaB downstream of MAVS through the recruitment of NEMO.
InnateDB Annotation from Orthologs
Summary
PMID 23951545
[Mus musculus] The binding of MAVS to Traf2, Traf5, and Traf6 is dependent on virus infection and MAVS polymerization. The TRAF proteins promote ubiquitination that recruits IKBKG binding to the MAVS signalling complex
Entrez Gene
Summary The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:211326615-211374946
Strand Forward strand
Band q32.3
Transcripts
ENST00000336184 ENSP00000336825
ENST00000261464 ENSP00000261464
ENST00000367004 ENSP00000355971
ENST00000462410
ENST00000488428
ENST00000494355
ENST00000473385
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 74 [view]
Protein-Protein 71 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0016567 protein ubiquitination
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0035631 CD40 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026637
View Gene Order
ENSBTAG00000012020
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
NetPath_21
RANKL pathway
NetPath_26
TWEAK pathway
REACTOME
KEGG
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523930 Hs.623582
RefSeq NM_001033910 NM_004619 NM_145759 XM_005273249
HUGO
OMIM
CCDS CCDS1497
HPRD 03834
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca