Version 5.4
Homo sapiens Protein: JAZF1
Summary
InnateDB Protein IDBP-10707.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JAZF1
Protein Name JAZF zinc finger 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000283928
InnateDB Gene IDBG-10703 (JAZF1)
Protein Structure
UniProt Annotation
Function Potential transcription factor.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations Note=A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. Translocation t(6;7)(p21;p22) with PHF1. {ECO:0000269PubMed:11371647, ECO:0000269PubMed:16397222}.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
PDB ID
InterPro IPR015880 Zinc finger, C2H2-like
PFAM
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86VZ6
PhosphoSite PhosphoSite-Q86VZ6
TrEMBL
UniProt Splice Variant
Entrez Gene 221895
UniGene Hs.368944
RefSeq NP_778231
HUGO HGNC:28917
OMIM 606246
CCDS CCDS5416
HPRD 09373
IMGT
EMBL AK091311 AL834234 AY372319 BC042441 CH236948
GenPept AAH42441 AAQ74874 BAG52333 CAD38912 EAL24212

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca