Homo sapiens Protein: CDC42BPA | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||
InnateDB Protein | IDBP-107079.7 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | CDC42BPA | ||||||||||||||||||||
Protein Name | CDC42 binding protein kinase alpha (DMPK-like) | ||||||||||||||||||||
Synonyms | MRCK; MRCKA; PK428; | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Protein | ENSP00000355729 | ||||||||||||||||||||
InnateDB Gene | IDBG-107075 (CDC42BPA) | ||||||||||||||||||||
Protein Structure | |||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||
Function | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. {ECO:0000269PubMed:11340065, ECO:0000269PubMed:11399775, ECO:0000269PubMed:15723050, ECO:0000269PubMed:18854160, ECO:0000269PubMed:20188707, ECO:0000269PubMed:21457715, ECO:0000269PubMed:9092543, ECO:0000269PubMed:9418861}. | ||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}. | ||||||||||||||||||||
Disease Associations | |||||||||||||||||||||
Tissue Specificity | Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. {ECO:0000269PubMed:9092543}. | ||||||||||||||||||||
Comments | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
|
||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||
PDB ID | |||||||||||||||||||||
InterPro |
IPR000095
CRIB domain IPR000719 Protein kinase domain IPR000961 AGC-kinase, C-terminal IPR001180 Citron-like IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001849 Pleckstrin homology domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR014930 Myotonic dystrophy protein kinase, coiled coil IPR017892 Protein kinase, C-terminal IPR017986 WD40-repeat-containing domain IPR020635 Tyrosine-protein kinase, catalytic domain |
||||||||||||||||||||
PFAM |
PF00786
PF00069 PF00780 PF07714 PF00169 PF00130 PF08826 PF00433 |
||||||||||||||||||||
PRINTS |
PR00109
|
||||||||||||||||||||
PIRSF | |||||||||||||||||||||
SMART |
SM00285
SM00133 SM00036 SM00233 SM00109 SM00220 SM00219 |
||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||
Modification | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | Q5VT25 | ||||||||||||||||||||
PhosphoSite | PhosphoSite-Q5VT25 | ||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 8476 | ||||||||||||||||||||
UniGene | Hs.623470 | ||||||||||||||||||||
RefSeq | NP_055641 | ||||||||||||||||||||
HUGO | HGNC:1737 | ||||||||||||||||||||
OMIM | 603412 | ||||||||||||||||||||
CCDS | CCDS1559 | ||||||||||||||||||||
HPRD | 04562 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AB007920 AB208968 AJ518975 AJ518976 AL353689 AL451047 AL627308 CR933723 U59305 | ||||||||||||||||||||
GenPept | AAB37126 BAA32296 BAD92205 CAD57745 CAD57746 CAH71183 CAH71184 CAH71185 CAH71336 CAH71337 CAH71338 CAI19108 CAI19109 CAI19110 CAI19113 CAI46252 | ||||||||||||||||||||