Homo sapiens Protein: CDC42BPA | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-107083.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CDC42BPA | ||||||||||||||||||
Protein Name | CDC42 binding protein kinase alpha (DMPK-like) | ||||||||||||||||||
Synonyms | MRCK; MRCKA; PK428; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000355728 | ||||||||||||||||||
InnateDB Gene | IDBG-107075 (CDC42BPA) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. {ECO:0000269PubMed:11340065, ECO:0000269PubMed:11399775, ECO:0000269PubMed:15723050, ECO:0000269PubMed:18854160, ECO:0000269PubMed:20188707, ECO:0000269PubMed:21457715, ECO:0000269PubMed:9092543, ECO:0000269PubMed:9418861}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. {ECO:0000269PubMed:9092543}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000095
CRIB domain IPR001180 Citron-like IPR001849 Pleckstrin homology domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain IPR014930 Myotonic dystrophy protein kinase, coiled coil IPR017986 WD40-repeat-containing domain |
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PFAM |
PF00786
PF00780 PF00169 PF00130 PF08826 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00285
SM00036 SM00233 SM00109 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q5VT25 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q5VT25 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 8476 | ||||||||||||||||||
UniGene | Hs.623470 | ||||||||||||||||||
RefSeq | XP_005273379 | ||||||||||||||||||
HUGO | HGNC:1737 | ||||||||||||||||||
OMIM | 603412 | ||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | 04562 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB007920 AB208968 AJ518975 AJ518976 AL353689 AL451047 AL627308 CR933723 U59305 | ||||||||||||||||||
GenPept | AAB37126 BAA32296 BAD92205 CAD57745 CAD57746 CAH71183 CAH71184 CAH71185 CAH71336 CAH71337 CAH71338 CAI19108 CAI19109 CAI19110 CAI19113 CAI46252 | ||||||||||||||||||