InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC42BPA

Summary

InnateDB Protein

IDBP-107087.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC42BPA

Protein Name

CDC42 binding protein kinase alpha (DMPK-like)

Synonyms

MRCK; MRCKA; PK428;

Species

Homo sapiens

Ensembl Protein

ENSP00000355726

InnateDB Gene

IDBG-107075 (CDC42BPA)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. {ECO:0000269PubMed:11340065, ECO:0000269PubMed:11399775, ECO:0000269PubMed:15723050, ECO:0000269PubMed:18854160, ECO:0000269PubMed:20188707, ECO:0000269PubMed:21457715, ECO:0000269PubMed:9092543, ECO:0000269PubMed:9418861}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. {ECO:0000269PubMed:9092543}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0016477	cell migration
GO:0031032	actomyosin structure organization
GO:0031532	actin cytoskeleton reorganization
GO:0035556	intracellular signal transduction
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0031252	cell leading edge
GO:0042641	actomyosin
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000095 CRIB domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014930 Myotonic dystrophy protein kinase, coiled coil
IPR017892 Protein kinase, C-terminal
IPR017986 WD40-repeat-containing domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM