InnateDB Protein
|
IDBP-107775.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ADSS
|
Protein Name
|
adenylosuccinate synthase
|
Synonyms
|
ADEH; ADSS 2;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000355493
|
InnateDB Gene
|
IDBG-107773 (ADSS)
|
Protein Structure
|
|
Function |
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
|
Subcellular Localization |
Cytoplasm. Note=Partially associated with particulate fractions.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
30
[view]
|
Protein-Protein |
27
[view]
|
Protein-DNA |
3
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001114
Adenylosuccinate synthetase
IPR027417
P-loop containing nucleoside triphosphate hydrolase
|
PFAM |
PF00709
|
PRINTS |
|
PIRSF |
|
SMART |
SM00788
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P30520
|
PhosphoSite |
PhosphoSite-P30520
|
TrEMBL |
A0A024R5Q7
|
UniProt Splice Variant |
|
Entrez Gene |
159
|
UniGene |
Hs.498313
|
RefSeq |
NP_001117
|
HUGO |
HGNC:292
|
OMIM |
103060
|
CCDS |
CCDS1624
|
HPRD |
00050
|
IMGT |
|
EMBL |
AL591594
AL645465
BC012356
CH471148
X66503
|
GenPept |
AAH12356
CAA47123
CAI14037
CAI15031
EAW77102
EAW77103
|
|
|