InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADSS

Summary

InnateDB Protein

IDBP-107775.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADSS

Protein Name

adenylosuccinate synthase

Synonyms

ADEH; ADSS 2;

Species

Homo sapiens

Ensembl Protein

ENSP00000355493

InnateDB Gene

IDBG-107773 (ADSS)

Protein Structure

UniProt Annotation

Function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Subcellular Localization

Cytoplasm. Note=Partially associated with particulate fractions.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	27 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004019	adenylosuccinate synthase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0042301	phosphate ion binding

Biological Process

GO:0002376	immune system process
GO:0006144	purine nucleobase metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006167	AMP biosynthetic process
GO:0006184	GTP catabolic process
GO:0006531	aspartate metabolic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0014074	response to purine-containing compound
GO:0044208	'de novo' AMP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046040	IMP metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0060359	response to ammonium ion
GO:0071257	cellular response to electrical stimulus