Version 5.4
Homo sapiens Gene: ADSS
Summary
InnateDB Gene IDBG-107773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADSS
Gene Name adenylosuccinate synthase
Synonyms ADEH; ADSS 2
Species Homo sapiens
Ensembl Gene ENSG00000035687
Encoded Proteins
IDBP-107775
adenylosuccinate synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:244408494-244452134
Strand Reverse strand
Band q44
Transcripts
ENST00000366535 ENSP00000355493
ENST00000468215
ENST00000462358
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 27 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004019 adenylosuccinate synthase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042301 phosphate ion binding
Biological Process
GO:0002376 immune system process
GO:0006144 purine nucleobase metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006167 AMP biosynthetic process
GO:0006184 GTP catabolic process
GO:0006531 aspartate metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0014074 response to purine-containing compound
GO:0044208 'de novo' AMP biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046040 IMP metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0060359 response to ammonium ion
GO:0071257 cellular response to electrical stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015961
View Gene Order
ENSBTAG00000013885
Not yet available
Pathways
NETPATH
REACTOME
REACT_1776
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Alanine Aspartate Asparagine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.498313
RefSeq NM_001126
HUGO
OMIM
CCDS CCDS1624
HPRD 00050
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca