InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPU

Summary

InnateDB Protein

IDBP-107804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPU

Protein Name

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

Synonyms

hnRNP U; HNRPU; SAF-A; U21.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000283179

InnateDB Gene

IDBG-107800 (HNRNPU)

Protein Structure

UniProt Annotation

Function

Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. {ECO:0000269PubMed:19029303}.

Subcellular Localization

Nucleus. Cytoplasm. Cell surface. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Also found associated with the cell surface.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 328 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	328 [view]
Protein-Protein	328 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0001649	osteoblast differentiation
GO:0006396	RNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0009986	cell surface
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0070937	CRD-mediated mRNA stability complex
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR001870 B30.2/SPRY domain
IPR003034 SAP domain
IPR003877 SPRY domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR010488 Zeta toxin domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02037
PF00622
PF06414

PRINTS

PIRSF

SMART

SM00513
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q00839