Homo sapiens Gene: HNRNPU
Summary
InnateDB Gene IDBG-107800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPU
Gene Name heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
Synonyms hnRNP U; HNRPU; SAF-A; U21.1;
Species Homo sapiens
Ensembl Gene ENSG00000153187
Encoded Proteins
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:244851166-244864542
Strand Reverse strand
Band q44
Transcripts
ENST00000366525
ENST00000283179 ENSP00000283179
ENST00000444376 ENSP00000393151
ENST00000440865 ENSP00000410728
ENST00000483966
ENST00000468690
ENST00000465881
ENST00000476241
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 328 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 328 [view]
Protein-Protein 328 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0001649 osteoblast differentiation
GO:0006396 RNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0070934 CRD-mediated mRNA stabilization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0009986 cell surface
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0070937 CRD-mediated mRNA stability complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.709028
RefSeq NM_004501 NM_031844
HUGO
OMIM
CCDS CCDS31081 CCDS41479
HPRD 04185
IMGT
EMBL
GenPept
RNA Seq Atlas