InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HNRNPU

Summary

InnateDB Gene

IDBG-107800.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPU

Gene Name

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

Synonyms

hnRNP U; HNRPU; SAF-A; U21.1

Species

Homo sapiens

Ensembl Gene

ENSG00000153187

Encoded Proteins

IDBP-107804

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

IDBP-390210

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

IDBP-390213

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:244851166-244864542

Strand

Reverse strand

Band

q44

Transcripts

ENST00000366525
ENST00000283179	ENSP00000283179
ENST00000444376	ENSP00000393151
ENST00000440865	ENSP00000410728
ENST00000483966
ENST00000468690
ENST00000465881
ENST00000476241

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 328 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	328 [view]
Protein-Protein	328 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0001649	osteoblast differentiation
GO:0006396	RNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0009986	cell surface
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0070937	CRD-mediated mRNA stability complex
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039630

View Gene Order

ENSBTAG00000007606

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q5RI18

UniProt Splice Variant

Entrez Gene

3192

UniGene

Hs.709028

RefSeq

NM_004501 NM_031844

HUGO

HGNC:5048

OMIM

602869

CCDS

CCDS31081 CCDS41479

HPRD

04185

IMGT

EMBL

BX323046

GenPept

RNA Seq Atlas

3192