InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CIDEA

Summary

InnateDB Protein

IDBP-1085.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CIDEA

Protein Name

cell death-inducing DFFA-like effector a

Synonyms

CIDE-A;

Species

Homo sapiens

Ensembl Protein

ENSP00000320209

InnateDB Gene

IDBG-1081 (CIDEA)

Protein Structure

UniProt Annotation

Function

Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. {ECO:0000250, ECO:0000269PubMed:19843876}.

Subcellular Localization

Lipid droplet {ECO:0000269PubMed:18509062}. Nucleus {ECO:0000250}. Note=Enriched at lipid droplet contact sites. Has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062). {ECO:0000250, ECO:0000269PubMed:18509062}.

Disease Associations

Note=In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin- resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. {ECO:0000269PubMed:18509062}.

Tissue Specificity

Expressed in omental and subcutaneous adipose tissue (at protein level). {ECO:0000269PubMed:18509062}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001659	temperature homeostasis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0006915	apoptotic process
GO:0008219	cell death
GO:0010890	positive regulation of sequestering of triglyceride
GO:0019915	lipid storage
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032720	negative regulation of tumor necrosis factor production
GO:0035634	response to stilbenoid
GO:0042981	regulation of apoptotic process
GO:0050710	negative regulation of cytokine secretion
GO:0050995	negative regulation of lipid catabolic process
GO:1900118	negative regulation of execution phase of apoptosis
GO:1902510	regulation of apoptotic DNA fragmentation