Homo sapiens Gene: CIDEA
Summary
InnateDB Gene IDBG-1081.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CIDEA
Gene Name cell death-inducing DFFA-like effector a
Synonyms CIDE-A;
Species Homo sapiens
Ensembl Gene ENSG00000176194
Encoded Proteins
cell death-inducing DFFA-like effector a
cell death-inducing DFFA-like effector a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:12254319-12277595
Strand Forward strand
Band p11.21
Transcripts
ENST00000320477 ENSP00000320209
ENST00000522713 ENSP00000429238
ENST00000521296
ENST00000520620
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001659 temperature homeostasis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006629 lipid metabolic process
GO:0006915 apoptotic process
GO:0008219 cell death
GO:0010890 positive regulation of sequestering of triglyceride
GO:0019915 lipid storage
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032720 negative regulation of tumor necrosis factor production
GO:0035634 response to stilbenoid
GO:0042981 regulation of apoptotic process
GO:0050710 negative regulation of cytokine secretion
GO:0050995 negative regulation of lipid catabolic process
GO:1900118 negative regulation of execution phase of apoptosis
GO:1902510 regulation of apoptotic DNA fragmentation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005811 lipid particle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.249129
RefSeq NM_001279 XM_006722297
HUGO
OMIM
CCDS CCDS11856
HPRD 08380
IMGT
EMBL
GenPept
RNA Seq Atlas