Version 5.4
Homo sapiens Protein: PRR5
Summary
InnateDB Protein IDBP-11036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRR5
Protein Name proline rich 5 (renal)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000337464
InnateDB Gene IDBG-11032 (PRR5)
Protein Structure
UniProt Annotation
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. {ECO:0000269PubMed:15718101, ECO:0000269PubMed:17599906}.
Subcellular Localization
Disease Associations
Tissue Specificity Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors. {ECO:0000269PubMed:15718101, ECO:0000269PubMed:17599906}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007049 cell cycle
Cellular Component
GO:0031932 TORC2 complex
Protein Structure and Domains
PDB ID
InterPro IPR013745 HbrB-like
PFAM PF08539
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P85299
PhosphoSite PhosphoSite-P85299
TrEMBL B1AHG4
UniProt Splice Variant
Entrez Gene 55615
UniGene Hs.597520
RefSeq NP_851850
HUGO HGNC:31682
OMIM 609406
CCDS CCDS14058
HPRD 18696
IMGT
EMBL AF177331 AK000192 AK055848 AK291564 BC016921 BK005635 BK005636 BK005637 BK005638 BK005639 CH471138 Z93244 Z98743
GenPept AAG17975 AAH16921 BAA90999 BAF84253 BAG51585 CAQ06711 CAQ06720 CAQ09256 CAQ09263 DAA05654 DAA05655 DAA05656 DAA05657 DAA05658 EAW73353 EAW73354 EAW73355 EAW73357

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca