Homo sapiens Gene: PRR5
Summary
InnateDB Gene IDBG-11032.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRR5
Gene Name proline rich 5 (renal)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186654
Encoded Proteins
proline rich 5 (renal)
proline rich 5 (renal)
proline rich 5 (renal)
proline rich 5 (renal)
proline rich 5 (renal)
proline rich 5 (renal)
proline rich 5 (renal)
proline rich 5 (renal)
proline rich 5 (renal)
proline rich 5 (renal)
proline rich 5 (renal)
proline rich 5 (renal)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:44668547-44737681
Strand Forward strand
Band q13.31
Transcripts
ENST00000006251 ENSP00000006251
ENST00000336985 ENSP00000337464
ENST00000403581 ENSP00000384848
ENST00000403696 ENSP00000384746
ENST00000432186 ENSP00000400925
ENST00000457960 ENSP00000410215
ENST00000431834 ENSP00000407637
ENST00000432916 ENSP00000392026
ENST00000455389 ENSP00000405404
ENST00000492475
ENST00000459857
ENST00000492289
ENST00000477331
ENST00000495017
ENST00000475850
ENST00000611394 ENSP00000480357
ENST00000624862 ENSP00000485597
ENST00000617066 ENSP00000479623
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007049 cell cycle
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Cellular Component
GO:0031932 TORC2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
mTOR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.102336 Hs.597520
RefSeq NM_001017528 NM_001017529 NM_001017530 NM_001198721 NM_015366 NM_181333
HUGO
OMIM
CCDS CCDS14058 CCDS14059 CCDS56232 CCDS74875
HPRD 18696
IMGT
EMBL
GenPept
RNA Seq Atlas