Version 5.4
Homo sapiens Protein: GGCT
Summary
InnateDB Protein IDBP-11118.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGCT
Protein Name gamma-glutamylcyclotransferase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000005374
InnateDB Gene IDBG-11114 (GGCT)
Protein Structure
UniProt Annotation
Function Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. {ECO:0000269PubMed:16765912, ECO:0000269PubMed:18515354}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003839 gamma-glutamylcyclotransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006750 glutathione biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR013024 Butirosin biosynthesis, BtrG-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75223
PhosphoSite PhosphoSite-O75223
TrEMBL
UniProt Splice Variant
Entrez Gene 79017
UniGene
RefSeq NP_001186745
HUGO HGNC:21705
OMIM 137170
CCDS CCDS56475
HPRD 12912
IMGT
EMBL AC005154 AK315608 BC000625 BC005356 BC013937 BC019243 CH471073
GenPept AAH00625 AAH05356 AAH13937 AAH19243 BAG37977 EAW93950 EAW93952 EAW93953

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca