Homo sapiens Gene: GGCT
Summary
InnateDB Gene IDBG-11114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGCT
Gene Name gamma-glutamylcyclotransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006625
Encoded Proteins
gamma-glutamylcyclotransferase
gamma-glutamylcyclotransferase
gamma-glutamylcyclotransferase
gamma-glutamylcyclotransferase
gamma-glutamylcyclotransferase
gamma-glutamylcyclotransferase
gamma-glutamylcyclotransferase
gamma-glutamylcyclotransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30496621-30551479
Strand Reverse strand
Band p14.3
Transcripts
ENST00000275428 ENSP00000275428
ENST00000005374 ENSP00000005374
ENST00000409144 ENSP00000386610
ENST00000409390 ENSP00000387235
ENST00000409436 ENSP00000386686
ENST00000440082 ENSP00000408015
ENST00000426081 ENSP00000390094
ENST00000447901 ENSP00000387809
ENST00000598361 ENSP00000470615
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003839 gamma-glutamylcyclotransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006750 glutathione biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glutathione conjugation pathway
Glutathione synthesis and recycling pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Glutathione metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL M0QZK8
UniProt Splice Variant
Entrez Gene 79017
UniGene
RefSeq NM_001199815 NM_001199816 NM_001199817 NM_024051
HUGO HGNC:21705
OMIM 137170
CCDS CCDS5428 CCDS56474 CCDS56475 CCDS56476
HPRD 12912
IMGT
EMBL AC005154
GenPept
RNA Seq Atlas 79017