Version 5.4
Homo sapiens Gene: GGCT
Summary
InnateDB Gene IDBG-11114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGCT
Gene Name gamma-glutamylcyclotransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006625
Encoded Proteins
IDBP-11116
gamma-glutamylcyclotransferase
IDBP-11118
gamma-glutamylcyclotransferase
IDBP-294528
gamma-glutamylcyclotransferase
IDBP-294512
gamma-glutamylcyclotransferase
IDBP-294527
gamma-glutamylcyclotransferase
IDBP-370679
gamma-glutamylcyclotransferase
IDBP-370688
gamma-glutamylcyclotransferase
IDBP-370689
gamma-glutamylcyclotransferase
IDBP-718346
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30496621-30551479
Strand Reverse strand
Band p14.3
Transcripts
ENST00000275428 ENSP00000275428
ENST00000005374 ENSP00000005374
ENST00000409144 ENSP00000386610
ENST00000409390 ENSP00000387235
ENST00000409436 ENSP00000386686
ENST00000440082 ENSP00000408015
ENST00000426081 ENSP00000390094
ENST00000447901 ENSP00000387809
ENST00000598361 ENSP00000470615
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003839 gamma-glutamylcyclotransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006750 glutathione biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002797
View Gene Order
ENSBTAG00000010597
Not yet available
Pathways
NETPATH
REACTOME
REACT_6960
Glutathione synthesis and recycling pathway
REACT_6926
Glutathione conjugation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00480
Glutathione metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0QZK8
UniProt Splice Variant
Entrez Gene 79017
UniGene
RefSeq NM_001199815 NM_001199816 NM_001199817 NM_024051
HUGO HGNC:21705
OMIM 137170
CCDS CCDS5428 CCDS56474 CCDS56475 CCDS56476
HPRD 12912
IMGT
EMBL AC005154
GenPept
RNA Seq Atlas 79017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca