InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUMB

Summary

InnateDB Protein

IDBP-11443.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUMB

Protein Name

numb homolog (Drosophila)

Synonyms

c14_5527; C14orf41; S171;

Species

Homo sapiens

Ensembl Protein

ENSP00000347169

InnateDB Gene

IDBG-11441 (NUMB)

Protein Structure

UniProt Annotation

Function

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Subcellular Localization

Membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0007411	axon guidance
GO:0021670	lateral ventricle development
GO:0021849	neuroblast division in subventricular zone
GO:0050769	positive regulation of neurogenesis