InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NUMB

Summary

InnateDB Gene

IDBG-11441.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUMB

Gene Name

numb homolog (Drosophila)

Synonyms

c14_5527; C14orf41; S171

Species

Homo sapiens

Ensembl Gene

ENSG00000133961

Encoded Proteins

IDBP-11443

numb homolog (Drosophila)

IDBP-11445

numb homolog (Drosophila)

IDBP-11447

numb homolog (Drosophila)

IDBP-593088

numb homolog (Drosophila)

IDBP-597808

numb homolog (Drosophila)

IDBP-592564

numb homolog (Drosophila)

IDBP-598285

numb homolog (Drosophila)

IDBP-586049

numb homolog (Drosophila)

IDBP-600608

numb homolog (Drosophila)

IDBP-595969

numb homolog (Drosophila)

IDBP-591307

numb homolog (Drosophila)

IDBP-602324

numb homolog (Drosophila)

IDBP-602016

numb homolog (Drosophila)

IDBP-595793

numb homolog (Drosophila)

IDBP-594730

numb homolog (Drosophila)

IDBP-588296

numb homolog (Drosophila)

IDBP-585589

numb homolog (Drosophila)

IDBP-598214

numb homolog (Drosophila)

IDBP-589000

numb homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24092752

[Mus musculus] Nod2 driven inflammation is regulated by nitric oxide responsive Mir146 that facilitates activation of sonic hedgehog (SHH) signalling by targeting Numb expression.

Entrez Gene

Summary

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:73275107-73463642

Strand

Reverse strand

Band

q24.3

Transcripts

ENST00000355058	ENSP00000347169
ENST00000359560	ENSP00000352563
ENST00000356296	ENSP00000348644
ENST00000554546	ENSP00000452416
ENST00000557597	ENSP00000451117
ENST00000555238	ENSP00000451300
ENST00000556772	ENSP00000451513
ENST00000555394	ENSP00000451625
ENST00000559312	ENSP00000452888
ENST00000560335	ENSP00000453209
ENST00000555738	ENSP00000452069
ENST00000554521	ENSP00000450817
ENST00000554014
ENST00000553997
ENST00000557486
ENST00000555859	ENSP00000451326
ENST00000555307	ENSP00000452357
ENST00000554394	ENSP00000451374
ENST00000554315
ENST00000556989
ENST00000555987	ENSP00000451559
ENST00000556112
ENST00000557774
ENST00000554818	ENSP00000451959
ENST00000557031
ENST00000556700
ENST00000556600
ENST00000553415
ENST00000557577
ENST00000557581
ENST00000544991	ENSP00000446001
ENST00000535282	ENSP00000441258

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0045294	alpha-catenin binding
GO:0045296	cadherin binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0007399	nervous system development
GO:0007405	neuroblast proliferation
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0021670	lateral ventricle development
GO:0021849	neuroblast division in subventricular zone
GO:0030862	positive regulation of polarized epithelial cell differentiation
GO:0030900	forebrain development
GO:0034332	adherens junction organization
GO:0045746	negative regulation of Notch signaling pathway
GO:0050769	positive regulation of neurogenesis
GO:0060487	lung epithelial cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016323	basolateral plasma membrane
GO:0019897	extrinsic component of plasma membrane
GO:0045177	apical part of cell

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021224

View Gene Order

ENSBTAG00000011683

Not yet available

Pathways

NETPATH

NetPath_3

Notch pathway

REACTOME

REACT_118614

Activated NOTCH1 Transmits Signal to the Nucleus pathway

REACT_22365

Recycling pathway of L1 pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_228134

Signaling by Hedgehog pathway

REACT_160082

Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway

REACT_160214

Signaling by NOTCH1 in Cancer pathway

REACT_18266

Axon guidance pathway

REACT_267605

Degradation of GLI1 by the proteasome pathway

REACT_160099

FBXW7 Mutants and NOTCH1 in Cancer pathway

REACT_111102

Signal Transduction pathway

REACT_267634

Hedgehog 'off' state pathway

REACT_160301

Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway

REACT_160248

Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway

REACT_299

Signaling by NOTCH pathway

REACT_118859

Signaling by NOTCH1 pathway

REACT_160133

Signaling by NOTCH1 HD Domain Mutants in Cancer pathway

REACT_116125

Disease pathway

KEGG

hsa04330

Notch signaling pathway pathway

INOH

PID NCI

met_pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

notch_pathway

Notch signaling pathway

Cross-References

SwissProt

TrEMBL

G3V433 G3V4S6

UniProt Splice Variant

Entrez Gene

8650

UniGene

Hs.654609 Hs.664337 Hs.714879

RefSeq

NM_001005743 NM_001005744 NM_001005745 NM_003744 XM_005268142 XM_005268143 XM_005268144 XM_005268145 XM_005268146 XM_006720283 XM_006720284 XM_006720285 XM_006720286 XM_006720287 XM_006720293 XM_006720294 XM_006720295 XM_006720296

HUGO

HGNC:8060

OMIM

603728

CCDS

CCDS32115 CCDS32116 CCDS55927 CCDS9814

HPRD

04767

IMGT

EMBL

AC004846 AC005280 AL391733

GenPept

RNA Seq Atlas

101928143 101930388 8650