Homo sapiens Gene: NUMB
Summary
InnateDB Gene IDBG-11441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUMB
Gene Name numb homolog (Drosophila)
Synonyms c14_5527; C14orf41; S171;
Species Homo sapiens
Ensembl Gene ENSG00000133961
Encoded Proteins
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
numb homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Nod2 driven inflammation is regulated by nitric oxide responsive Mir146 that facilitates activation of sonic hedgehog (SHH) signalling by targeting Numb expression.
Entrez Gene
Summary The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:73275107-73463642
Strand Reverse strand
Band q24.3
Transcripts
ENST00000355058 ENSP00000347169
ENST00000359560 ENSP00000352563
ENST00000356296 ENSP00000348644
ENST00000554546 ENSP00000452416
ENST00000557597 ENSP00000451117
ENST00000555238 ENSP00000451300
ENST00000556772 ENSP00000451513
ENST00000555394 ENSP00000451625
ENST00000559312 ENSP00000452888
ENST00000560335 ENSP00000453209
ENST00000555738 ENSP00000452069
ENST00000554521 ENSP00000450817
ENST00000554014
ENST00000553997
ENST00000557486
ENST00000555859 ENSP00000451326
ENST00000555307 ENSP00000452357
ENST00000554394 ENSP00000451374
ENST00000554315
ENST00000556989
ENST00000555987 ENSP00000451559
ENST00000556112
ENST00000557774
ENST00000554818 ENSP00000451959
ENST00000557031
ENST00000556700
ENST00000556600
ENST00000553415
ENST00000557577
ENST00000557581
ENST00000544991 ENSP00000446001
ENST00000535282 ENSP00000441258
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 45 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
Biological Process
GO:0007219 Notch signaling pathway
GO:0007399 nervous system development
GO:0007405 neuroblast proliferation
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0021670 lateral ventricle development
GO:0021849 neuroblast division in subventricular zone
GO:0030862 positive regulation of polarized epithelial cell differentiation
GO:0030900 forebrain development
GO:0034332 adherens junction organization
GO:0045746 negative regulation of Notch signaling pathway
GO:0050769 positive regulation of neurogenesis
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016323 basolateral plasma membrane
GO:0019897 extrinsic component of plasma membrane
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Notch pathway
REACTOME
Developmental Biology pathway
Signaling by Hedgehog pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 in Cancer pathway
Axon guidance pathway
Degradation of GLI1 by the proteasome pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
Recycling pathway of L1 pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
L1CAM interactions pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Disease pathway
KEGG
Notch signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Notch signaling pathway
Cross-References
SwissProt P49757
TrEMBL G3V4S6 Q5D0E5
UniProt Splice Variant
Entrez Gene 8650
UniGene Hs.654609 Hs.664337 Hs.714879
RefSeq NM_001005745 NM_003744 NM_001005743 NM_001005744 XM_006720284 XM_005268143 XM_006720283 XM_005268142 XM_006720287 XM_006720286 XM_005268146 XM_006720285 XM_005268145 XM_005268144 XM_006720296 XM_006720295 XM_006720294 XM_006720293
HUGO HGNC:8060
OMIM 603728
CCDS CCDS32116 CCDS55927 CCDS32115 CCDS9814
HPRD 04767
IMGT
EMBL AC004846 AC005280 AF015040 AF108092 AF109907 AF171938 AF171939 AF171940 AF171941 AK294591 AK304193 AL391733 BC020788 BC033824 BC068476 BX248073 CH471061 EU265734 EU265735 EU265736 EU265737 EU265738 L40393
GenPept AAC42000 AAC97962 AAD01548 AAD27959 AAD54279 AAD54280 AAD54281 AAD54282 AAH20788 AAH33824 AAH68476 ABY89090 ABY89091 ABY89092 ABY89093 ABY89094 BAG57779 BAG65073 CAD62362 EAW81106
RNA Seq Atlas 101928143 101930388 8650