InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAPD7

Summary

InnateDB Protein

IDBP-11698.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAPD7

Protein Name

PAP associated domain containing 7

Synonyms

LAK-1; LAK1; POLK; POLS; TRF4; TRF4-1; TRF41; TUTASE5;

Species

Homo sapiens

Ensembl Protein

ENSP00000230859

InnateDB Gene

IDBG-11696 (PAPD7)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. {ECO:0000269PubMed:23376078}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0004652	polynucleotide adenylyltransferase activity
GO:0016779	nucleotidyltransferase activity
GO:0043221	SMC family protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006261	DNA-dependent DNA replication
GO:0006302	double-strand break repair
GO:0007062	sister chromatid cohesion
GO:0007076	mitotic chromosome condensation
GO:0042493	response to drug