InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPARA

Summary

InnateDB Protein

IDBP-11788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARA

Protein Name

peroxisome proliferator-activated receptor alpha

Synonyms

hPPAR; NR1C1; PPAR; PPARalpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000262735

InnateDB Gene

IDBG-11786 (PPARA)

Protein Structure

UniProt Annotation

Function

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269PubMed:10195690, ECO:0000269PubMed:7629123, ECO:0000269PubMed:7684926, ECO:0000269PubMed:9556573}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Skeletal muscle, liver, heart and kidney. {ECO:0000269PubMed:7981125, ECO:0000269PubMed:8993548}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	59 [view]
Protein-Protein	53 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006629	lipid metabolic process
GO:0010467	gene expression
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010871	negative regulation of receptor biosynthetic process
GO:0010887	negative regulation of cholesterol storage
GO:0010891	negative regulation of sequestering of triglyceride
GO:0015908	fatty acid transport
GO:0030522	intracellular receptor signaling pathway
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0032099	negative regulation of appetite
GO:0032922	circadian regulation of gene expression
GO:0042752	regulation of circadian rhythm
GO:0043401	steroid hormone mediated signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045820	negative regulation of glycolytic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046321	positive regulation of fatty acid oxidation
GO:0072363	regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter
GO:0072366	regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369	regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003074 Peroxisome proliferator-activated receptor
IPR003076 Peroxisome proliferator-activated receptor, alpha
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR01288
PR01289

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt