Homo sapiens Protein: FBXL14
Summary
InnateDB Protein IDBP-11859.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL14
Protein Name F-box and leucine-rich repeat protein 14
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000344855
InnateDB Gene IDBG-11857 (FBXL14)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1. {ECO:0000269PubMed:19955572}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19955572}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR001810 F-box domain
IPR006553 Leucine-rich repeat, cysteine-containing subtype
IPR013101 Leucine-rich repeat 2
PFAM PF00560
PF13504
PF13855
PF00646
PF12937
PF13013
PF07723
PRINTS
PIRSF
SMART SM00256
SM00367
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N1E6
PhosphoSite PhosphoSite-Q8N1E6
TrEMBL
UniProt Splice Variant
Entrez Gene 144699
UniGene Hs.738521
RefSeq NP_689654
HUGO HGNC:28624
OMIM 609081
CCDS CCDS8509
HPRD 10949
IMGT
EMBL BC028132
GenPept AAH28132