Homo sapiens Gene: FBXL14
Summary
InnateDB Gene IDBG-11857.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL14
Gene Name F-box and leucine-rich repeat protein 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171823
Encoded Proteins
F-box and leucine-rich repeat protein 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:1565993-1594165
Strand Reverse strand
Band p13.33
Transcripts
ENST00000339235 ENSP00000344855
ENST00000543278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.367956 Hs.680521 Hs.738521
RefSeq NM_152441
HUGO
OMIM
CCDS CCDS8509
HPRD 10949
IMGT
EMBL
GenPept
RNA Seq Atlas