Homo sapiens Gene: FBXL14
Summary
InnateDB Gene IDBG-11857.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL14
Gene Name F-box and leucine-rich repeat protein 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171823
Encoded Proteins
F-box and leucine-rich repeat protein 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:1565993-1594165
Strand Reverse strand
Band p13.33
Transcripts
ENST00000339235 ENSP00000344855
ENST00000543278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q8N1E6
TrEMBL
UniProt Splice Variant
Entrez Gene 144699
UniGene Hs.367956 Hs.680521 Hs.738521
RefSeq NM_152441
HUGO HGNC:28624
OMIM 609081
CCDS CCDS8509
HPRD
IMGT
EMBL BC028132
GenPept AAH28132
RNA Seq Atlas 144699