Version 5.4
Homo sapiens Protein: SLC25A37
Summary
InnateDB Protein IDBP-12033.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A37
Protein Name solute carrier family 25, member 37
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000290075
InnateDB Gene IDBG-12031 (SLC25A37)
Protein Structure
UniProt Annotation
Function Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0044281 small molecule metabolic process
GO:0055072 iron ion homeostasis
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain
PFAM PF00153
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NYZ2
PhosphoSite PhosphoSite-Q9NYZ2
TrEMBL
UniProt Splice Variant
Entrez Gene 51312
UniGene Hs.726050
RefSeq
HUGO HGNC:29786
OMIM 610387
CCDS
HPRD 17605
IMGT
EMBL AF155660 AF223466 AK223194 AL833186 AY032628 BC015013 BC132799 BC132801 CH471080
GenPept AAF64141 AAF67479 AAH15013 AAI32800 AAI32802 AAK38154 BAD96914 CAH10415 EAW63617

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca