InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FKBP4

Summary

InnateDB Protein

IDBP-12315.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FKBP4

Protein Name

FK506 binding protein 4, 59kDa

Synonyms

FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52; PPIase;

Species

Homo sapiens

Ensembl Protein

ENSP00000001008

InnateDB Gene

IDBG-12313 (FKBP4)

Protein Structure

UniProt Annotation

Function

Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269PubMed:1279700, ECO:0000269PubMed:1376003, ECO:0000269PubMed:19945390, ECO:0000269PubMed:21730050, ECO:0000269PubMed:2378870}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:1279700}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	86 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0005528	FK506 binding
GO:0030674	protein binding, bridging
GO:0031072	heat shock protein binding
GO:0032767	copper-dependent protein binding
GO:0035259	glucocorticoid receptor binding
GO:0044822	poly(A) RNA binding
GO:0048156	tau protein binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0006463	steroid hormone receptor complex assembly
GO:0006825	copper ion transport
GO:0007566	embryo implantation
GO:0010977	negative regulation of neuron projection development
GO:0030521	androgen receptor signaling pathway
GO:0030850	prostate gland development
GO:0031111	negative regulation of microtubule polymerization or depolymerization
GO:0031115	negative regulation of microtubule polymerization
GO:0031503	protein complex localization
GO:0046661	male sex differentiation
GO:0048608	reproductive structure development
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005874	microtubule
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0044295	axonal growth cone
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00254
PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q02790