Version 5.4
Homo sapiens Gene: FKBP4
Summary
InnateDB Gene IDBG-12313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP4
Gene Name FK506 binding protein 4, 59kDa
Synonyms FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52; PPIase
Species Homo sapiens
Ensembl Gene ENSG00000004478
Encoded Proteins
IDBP-12315
FK506 binding protein 4, 59kDa
IDBP-599203
FK506 binding protein 4, 59kDa
IDBP-585542
FK506 binding protein 4, 59kDa
IDBP-585483
FK506 binding protein 4, 59kDa
IDBP-590874
FK506 binding protein 4, 59kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:2794953-2805423
Strand Forward strand
Band p13.33
Transcripts
ENST00000001008 ENSP00000001008
ENST00000543769 ENSP00000439703
ENST00000540260
ENST00000538622 ENSP00000446368
ENST00000543037
ENST00000539181 ENSP00000438491
ENST00000544366 ENSP00000442193
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 86 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005528 FK506 binding
GO:0030674 protein binding, bridging
GO:0031072 heat shock protein binding
GO:0032767 copper-dependent protein binding
GO:0035259 glucocorticoid receptor binding
GO:0044822 poly(A) RNA binding
GO:0048156 tau protein binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0006463 steroid hormone receptor complex assembly
GO:0006825 copper ion transport
GO:0007566 embryo implantation
GO:0010977 negative regulation of neuron projection development
GO:0030521 androgen receptor signaling pathway
GO:0030850 prostate gland development
GO:0031111 negative regulation of microtubule polymerization or depolymerization
GO:0031115 negative regulation of microtubule polymerization
GO:0031503 protein complex localization
GO:0046661 male sex differentiation
GO:0048608 reproductive structure development
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005874 microtubule
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0044295 axonal growth cone
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030357
View Gene Order
ENSBTAG00000007605
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_200624
Attenuation phase pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_200819
Cellular response to heat stress pathway
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 2288
UniGene Hs.524183 Hs.598828
RefSeq NM_002014
HUGO HGNC:3720
OMIM 600611
CCDS CCDS8512
HPRD 11794
IMGT
EMBL
GenPept
RNA Seq Atlas 2288

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca