InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGKC

Summary

InnateDB Protein

IDBP-123551.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGKC

Protein Name

immunoglobulin kappa constant

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000374777

InnateDB Gene

IDBG-123549 (IGKC)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]: A disease characterized by the complete absence of immunoglobulin kappa chains. {ECO:0000269PubMed:3931219}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0005515	protein binding

Biological Process

GO:0001895	retina homeostasis
GO:0006955	immune response
GO:0006956	complement activation
GO:0006958	complement activation, classical pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0050776	regulation of immune response

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle