InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFAP4

Summary

InnateDB Protein

IDBP-12591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFAP4

Protein Name

transcription factor AP-4 (activating enhancer binding protein 4)

Synonyms

AP-4; bHLHc41;

Species

Homo sapiens

Ensembl Protein

ENSP00000204517

InnateDB Gene

IDBG-12589 (TFAP4)

Protein Structure

UniProt Annotation

Function

Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'- CAGCTG-3'.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008285	negative regulation of cell proliferation
GO:0010629	negative regulation of gene expression
GO:0043065	positive regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0043922	negative regulation by host of viral transcription
GO:0043923	positive regulation by host of viral transcription
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071157	negative regulation of cell cycle arrest
GO:0071549	cellular response to dexamethasone stimulus
GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway