InnateDB Protein
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IDBP-12737.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARPP19
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Protein Name
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cAMP-regulated phosphoprotein, 19kDa
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Synonyms
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ARPP-16; ARPP-19; ARPP16; ENSAL;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000249822
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InnateDB Gene
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IDBG-12735 (ARPP19)
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Protein Structure
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Function |
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269PubMed:21164014}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006760
Endosulphine
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PFAM |
PF04667
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P56211
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PhosphoSite |
PhosphoSite-P56211
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TrEMBL |
H3BTD3
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UniProt Splice Variant |
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Entrez Gene |
10776
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UniGene |
Hs.743254
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RefSeq |
NP_006619
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HUGO |
HGNC:16967
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OMIM |
605487
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CCDS |
CCDS32242
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HPRD |
09264
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IMGT |
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EMBL |
AC025917
AF084555
AJ223091
AK311751
AL833077
BC003418
BC100015
CH471082
CR457132
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GenPept |
AAD52044
AAH03418
AAI00016
BAG34694
CAA11115
CAD89929
CAG33413
EAW77454
EAW77455
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