Homo sapiens Gene: ARPP19
Summary
InnateDB Gene IDBG-12735.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARPP19
Gene Name cAMP-regulated phosphoprotein, 19kDa
Synonyms ARPP-16; ARPP-19; ARPP16; ENSAL;
Species Homo sapiens
Ensembl Gene ENSG00000128989
Encoded Proteins
cAMP-regulated phosphoprotein, 19kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:52547045-52569883
Strand Reverse strand
Band q21.2
Transcripts
ENST00000249822 ENSP00000249822
ENST00000568196 ENSP00000457805
ENST00000569281 ENSP00000454297
ENST00000567669 ENSP00000455151
ENST00000566423 ENSP00000455625
ENST00000567830 ENSP00000457123
ENST00000563566 ENSP00000457631
ENST00000569723 ENSP00000455610
ENST00000561650 ENSP00000454234
ENST00000565288
ENST00000564163 ENSP00000454612
ENST00000561971 ENSP00000454341
ENST00000563277 ENSP00000455986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 5 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0005102 receptor binding
GO:0008601 protein phosphatase type 2A regulator activity
GO:0015459 potassium channel regulator activity
GO:0019212 phosphatase inhibitor activity
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0007212 dopamine receptor signaling pathway
GO:0043086 negative regulation of catalytic activity
GO:0045722 positive regulation of gluconeogenesis
GO:0046326 positive regulation of glucose import
GO:0046579 positive regulation of Ras protein signal transduction
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cell Cycle pathway
M Phase pathway
Mitotic Prophase pathway
MASTL Facilitates Mitotic Progression pathway
Cell Cycle, Mitotic pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.623537 Hs.728636 Hs.743254
RefSeq NM_006628 XM_005254132 XM_005254133 XM_005254134 XM_005254135
HUGO
OMIM
CCDS CCDS32242
HPRD 09264
IMGT
EMBL
GenPept
RNA Seq Atlas